The most frequently prescribed oral antidiabetic drug metformin significantly affects metabolic pathways. This was reported by scientists from the Helmholtz Zentrum München together with colleagues from the German Diabetes ...
Sep 15, 2016
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A growing body of scientific and medical evidence continues to shed light on the complex interaction between metabolic pathways affected by microrganisms living in the human gut and gene expression, immune function, and inflammation ...
Aug 9, 2016
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Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant- a lethal condition. ...
May 26, 2016
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Fragile X syndrome (FXS) is the most common genetically inherited cause of intellectual disability in humans. New research shows how the hormone insulin—usually associated with diabetes—is involved in the daily activity ...
Apr 26, 2016
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A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The ...
Apr 6, 2016
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As the study shows, a high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring. These changes affect metabolic pathways regulated by the gut hormone GIP, whereby the adult offspring are more ...
Feb 1, 2016
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A failing heart is said to be like an "engine out of fuel." To better understand the problem of energy production in heart-failure patients, researchers at Yale University and Duke University studied the underlying metabolic ...
Jan 29, 2016
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What can a rare genetic childhood disease teach us about cancer? Dr. Ayelet Erez of the Weizmann Institute's Biological Regulation Department says: "A single-mutation disease can act as a 'lens.' If we find exactly what malfunctions ...
Nov 30, 2015
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Just as poultry is steadily gaining in popularity on dinner plates, the chicken is growing in attractiveness as a biomedical model for studying health issues ranging from headaches and ovarian cancer to cystic fibrosis and ...
Oct 29, 2015
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The protein complex mTORC1 is a central regulator of cell metabolism. In the active state, it stimulates anabolic processes and increases the production and storage of proteins and lipids. Researchers from the German Leibniz ...
Jun 30, 2015
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