Addiction

Past-year methamphetamine use 6.6 per 1,000 in 2015 to 2018

The estimated rate of past-year methamphetamine use was 6.6 per 1,000 adults during 2015 to 2018, according to research published in the March 27 issue of the U.S. Centers for Disease Control and Prevention Morbidity and ...

Addiction

U.S. saw big rise in meth, fentanyl use in 2019

(HealthDay)—A study of over 1 million urine drug tests from across the United States shows soaring rates of use of methamphetamines and fentanyl, often used together in potentially lethal ways.

Genetics

Impact of meth use depends on your genes

New research led by La Trobe University has uncovered genetic clues which could explain why some people have more severe side effects from long-term methamphetamine use than others.

Medications

Co-addiction of meth and opioids hinders treatment

Judith Tsui, a UW Medicine clinician specializing in addiction treatment, was seeing more and more patients she was treating for opioid-use disorder also using methamphetamines, a powerful, highly addictive stimulant that ...

Cardiology

Stopping meth helps reverse drug-induced heart failure

Heart failure is more severe when it stems from using methamphetamine, but heart failure patients who get proper medical treatment and are able to stop using meth can improve just as much as patients who never used meth, ...

Medications

Methamphetamine prices drop to record low

The price of a gram of methamphetamine has dropped to record lows in three North Island regions, while many South Island regions are also reporting substantial declines in prices for the drug.

Addiction

Spending on illicit drugs in US nears $150 billion annually

Spending on cannabis, cocaine, heroin and methamphetamine by Americans reached nearly $150 billion in 2016, with a large proportion of spending coming from the small share of people who use drugs on a daily or near-daily ...

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Methamphetamine

Methamphetamine (/mɛθæm'fɛtəmiːn/ also known as metamfetamine (INN), methylamphetamine, N-methylamphetamine, and desoxyephedrine) is a psychostimulant and sympathomimetic drug.

A member of the family of phenylethylamines, methamphetamine is chiral, with two isomers:

The levorotary form, called levomethamphetamine, is an over-the-counter drug used in inhalers for nasal decongestion. Levomethamphetamine does not possess any significant central nervous system activity or addictive properties. The remainder of this article deals only with the dextrorotatory form, called dextromethamphetamine, and the racemic form.

Methamphetamine enters the brain and triggers a cascading release of dopamine, serotonin and norepinephrine. It is highly active in the mesolimbic reward pathways of the brain, inducing intense euphoria, with risk for addiction. To a lesser extent, methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor with high concentrations serving as a monoamine oxidase inhibitor. Users may become hypersexual or obsessed with a task, thought or activity. Withdrawal is characterized by excessive sleeping, eating, and major depression, often accompanied by anxiety and drug-craving. Methamphetamine users may take sedatives such as benzodiazepines as a means of easing their "come down", anxiety or enable them to sleep.

Methamphetamine has medical uses as well as the potential to cause addiction. Methamphetamine addiction typically occurs when a person begins to use the drug as a stimulant, for its powerful enhancing effects on sex, mood and energy, alertness and ability to concentrate, and weight loss and appetite suppression, among its other psychological and physical effects.[citation needed] Over time tolerance develops, and users have greater difficulty functioning and experiencing pleasure than they did before, which persists indefinitely due to neurotoxicity produced by methamphetamine in long-term recovered addicts.[citation needed]

Nicknames for methamphetamine are numerous and vary significantly from region to region, some common nicknames for methamphetamine include "crank", "meth", "ice", "crystal", "glass", "shabu" or "syabu" (Philippines), "tik" (South Africa), "P" (New Zealand), "piko" (Slovakia), and "yaa baa" (Thailand). Methamphetamine is sometimes referred to as "speed", but this term is generally reserved for regular amphetamine and dextroamphetamine.

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