Cancer onset prevention is considered to be the most important and cost-effective long-term measure for cancer prevention. However, since the molecular mechanisms by which premalignant lesions and very early cancers begin ...
Nov 8, 2021
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A computer model developed by Cleveland Clinic oncologist Timothy Chan, MD, Ph.D., and colleagues accurately predicts whether immune checkpoint blockade (ICB) will be effective in patients diagnosed with a wide variety of ...
Nov 4, 2021
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A Ludwig Cancer Research study has identified a means by which cancer cells engineer the conversion of immune cells known as macrophages from destroyers of tumors to supporters of their growth and survival. The new research, ...
Oct 25, 2021
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Reactive oxygen species (ROS) can act as signal carriers during the evolution of malignant tumors. At the appropriate concentration, ROS mediate signal transduction and cell growth. However, ROS are a double-edged sword, ...
Oct 20, 2021
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Cancerous tumors are made up of many more components than just malignant cells from the tissue of origin. Immune cells can be recruited to the tumor site and form what is known as the tumor microenvironment. A subset of these ...
Oct 18, 2021
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Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed macrophage–tumor chimeric exosomes that co-activate the immune response and tumor microenvironment to support ...
Oct 13, 2021
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The international team led by Dr. Jacqui McGovern, from the Centre for Biomedical Technologies, used tissue engineering and regenerative medicine principles to create primary tumors with their microenvironment and humanized ...
Sep 28, 2021
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Immunotherapy drugs are promising new weapons in the fight against cancer, but they are so strong that they can be toxic to the rest of the human body. The basic idea behind immunotherapy drugs is simple. Doctors inject special ...
Sep 13, 2021
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More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps. Two ...
Aug 18, 2021
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A form of cell communication called hedgehog signaling is vital for embryonic development in mammals. But aberrantly activated hedgehog signaling in multiple cancer types—including breast cancer—promotes tumor invasion, ...
Aug 16, 2021
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