Genetics

Rare congenital heart defect rescued by protease inhibition

A research team at the Greenwood Genetic Center (GGC) has successfully used small molecules to restore normal heart and valve development in an animal model for Mucolipidosis II (ML II), a rare genetic disorder. Progressive ...

Medications

Inhibiting epileptic activity in the brain

Epileptic seizures often originate in small, localized areas of the brain where neurons abnormally fire in unison. These electrical impulses disrupt proper brain functioning and cause seizures. But what makes regions where ...

Genetics

Researchers discover a rare genetic form of dementia

A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain—which causes this newly discovered ...

Immunology

Steering the immune system with liposomes

Liposomes—nano-sized spheres composed of fatty molecules—are very promising for vaccination. Bio-pharmaceutical scientist Naomi Benne discovered that the immune response in animal models can be steered by varying the ...

Arthritis & Rheumatism

3-D bioprinting constructs for cartilage regeneration

Cartilage injury is a common cause of joint dysfunction and existing joint prostheses cannot remodel with host joint tissue. However, it is challenging to develop large-scale biomimetic anisotropic constructs that structurally ...

Oncology & Cancer

Increasing the effectiveness of immunotherapy against skin cancer

The melanoma is a malignant tumor of the pigment cells. If diagnosed early, the tumor can be removed completely—and the chances of recovery are good. But in later stages, when the tumor has already spread or formed metastases ...

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