Diseases, Conditions, Syndromes

Long-term dupilumab benefits adolescents with eczema

Results from a phase IIa open-label trial and a subsequent phase III open-label extension trial reinforce findings from an earlier short-term trial that adolescents with moderate-to-severe atopic dermatitis, or eczema, can ...

Oncology & Cancer

Researchers convert pro-tumor macrophages into cancer killers

Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to become highly metastatic. In a paper published in Cancer Research, University ...

Diseases, Conditions, Syndromes

Ebola expert weighs in on news of a potential cure

Scientists recently reported that two treatments saved the lives of people infected with the Ebola virus—with the New York Times reporting that roughly 90% of newly infected patients were saved—suggesting we are ever ...

Overweight & Obesity

Gut-brain connection helps explain how overeating leads to obesity

Eating extra servings typically shows up on the scale later, but how this happens has not been clear. A new study published today in the Journal of Clinical Investigation by a multi-institutional team led by researchers at ...

Diseases, Conditions, Syndromes

New study uncovers weakness in C. diff toxin

A new study, led by researchers from the University of California, Irvine (UCI), uncovers the long-sought-after, three-dimensional structure of a toxin primarily responsible for devastating Clostridium difficile infection ...

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Monoclonal antibodies

Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are identical because they are produced by one type of immune cell that are all clones of a single parent cell. Given almost any substance, it is possible to create monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the generic drug name ends in -mab (see "Nomenclature of monoclonal antibodies").

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