The secret to melanoma's metastatic spread could be a complex natural pathway it hijacks—one which may be a therapeutic target in combination with other targeted therapies and immunotherapies, according to new research ...
Nov 17, 2021
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According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks ...
Aug 25, 2021
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487
Wei Yan, MD, Ph.D., and his research group have solved a longstanding mystery and scientific debate about the mechanism underlying the gamete and embryo transport within the fallopian tube. Using a mouse model that lacked ...
May 24, 2021
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Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders. ...
Dec 23, 2020
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Bacteria in the small intestine can deaminate levodopa, the main drug that is used to treat Parkinson's disease. Bacterial processing of the unabsorbed fractions of the drug results in a metabolite that reduces gut motility. ...
Oct 19, 2020
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124
According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells. These messages are packaged into particles called ...
Aug 10, 2020
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Newly produced spermatozoa within the testis are not fully functional until they mature in the epididymis, a duct that helps to transport and store sperm. Male infertility may arise from lack of communication between the ...
Jul 9, 2020
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Lurking just beneath the surface of just about every common nursery rhyme is a complex record of times long gone. For example, the "crooked man" who "laid a crooked sixpence upon a crooked style" was none other than the great ...
Enlarged cerebral ventricles are found in 80% of individuals with schizophrenia, yet the mechanisms that lead to ventricular enlargement are mostly unknown. Scientists at St. Jude Children's Research Hospital have found that ...
Feb 14, 2020
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203
Federal regulations may keep lung cancer patients out of clinical trials simply because these patients are on medications that might affect the electrical system of the heart. Drilling into the details quickly turns up reasons ...
Dec 11, 2019
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