On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, ...
Mar 22, 2024
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Motor neurons are the cells the brain uses to command muscles to act. Scientists typically thought of them as simple connections, much like the cables that link computers with their accessories. Now, in fly studies, researchers ...
Mar 20, 2024
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A mutated protein expressed in lysosomes may contribute to Parkinson's disease, according to a new Northwestern Medicine study published in the Journal of Cell Biology.
Mar 12, 2024
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UT Southwestern Medical Center researchers have identified an experimental molecular compound that improved survival among cellular models and mouse models of amyotrophic lateral sclerosis (ALS), the fatal neurodegenerative ...
Feb 6, 2024
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Life has a challenging tempo. Sometimes, it moves faster or slower than we'd like. Nevertheless, we adapt. We pick up the rhythm of conversations. We keep pace with the crowd walking a city sidewalk.
Jan 30, 2024
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Only a fraction of people who sustain a spinal cord injury fully regain their motor function. While rehabilitation can help, scientists have long looked for ways to regenerate injured nerve fibers—including, at Boston Children's ...
Jan 25, 2024
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Researchers at Nagoya University in Japan have discovered a relationship between the progression of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the disruption of mitochondria-associated membranes ...
Jan 17, 2024
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In neuromuscular diseases, neurons and muscle cells stop communicating properly. Researchers led by Mina Gouti can now model this in 2D in a culture dish. Writing about their findings in Nature Communications, they say the ...
Dec 19, 2023
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Spinal muscular atrophy (SMA) is a devastating pediatric neuromuscular disorder caused by loss-of-function mutations in the SMN1 gene, which prevents the body from producing enough of the survival motor neuron (SMN) protein ...
Dec 7, 2023
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Modulating the activity of a kinase in motor neurons may help mitigate mitochondrial defects and other symptoms of spinal muscular atrophy, offering a new therapeutic avenue for the devastating disease, according to a Northwestern ...
Dec 5, 2023
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