Oncology & Cancer

Blocking tumor signals can hinder cancer's spread

For most people who die of cancer, the spread of the initial tumor is to blame. "Metastasis is what kills most cancer patients," says Serge Fuchs, a professor in Penn's School of Veterinary Medicine. "Yet there are not many, ...

Medical research

Mouse model mimics SARS-CoV-2 infection in humans

A mouse model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduces features observed in human patients, researchers report May 26 in the journal Cell Host & Microbe. Using CRISPR/Cas9 ...

Medical research

Study probes efficacy of APOSEC for allergic skin lesions

APOSEC is a biologic wound-healing agent developed by thoracic surgeon Hendrik Jan Ankersmit from MedUni Vienna. Together with dermatological basic researcher Michael Mildner, also from MedUni Vienna, he has now also investigated ...

Immunology

Immune system discovery could end chronic organ rejection

Chronic rejection of transplanted organs is the leading cause of transplant failure, and one that the field of organ transplantation has not overcome in almost six decades since the advent of immunosuppressive drugs enabled ...

Immunology

Transporter's role in gut barrier linked to intestinal dysfunction

The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane of many cell types, including intestinal epithelial cells. Two patients with mutations in NKCC1 suffered from severe intestinal dysfunction ...

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