Mutations in the enzyme IDH (isocitrate dehydrogenase) are found in 15–20% of acute myeloid leukemia (AML) cases. IDH mutations have been shown to impact cellular differentiation and DNA and histone methylation, but little ...
Dec 13, 2021
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An international team has developed statistical models to predict the risk of early death in patients being treated with non-intensive therapies for acute myeloid leukemia (AML). Results of analyses using the models will ...
Dec 12, 2021
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A functional precision medicine study conducted in Finland demonstrates that treatment selection based on results from drug sensitivity testing of patients' cells can be clinically useful in patients with aggressive hematological ...
Nov 17, 2021
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Acute myeloid leukemia (AML) is the second most common leukemia diagnosed in children. It is hard to treat and can be fatal in some cases. While there have been some recent successes with genetically targeted therapies for ...
Nov 5, 2021
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The journal Oncotarget has published "Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal ...
Nov 2, 2021
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Inositol is a sugar required for cells to survive. Most cells either get it from the bloodstream or make it themselves. Since there is plenty of inositol available, some cancer cells decide to stop making it. Cold Spring ...
Oct 27, 2021
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Mount Sinai researchers have developed a therapy that shows promise against a deadly pediatric leukemia. The small-molecule therapy was highly effective in fighting a type of acute myeloid leukemia in both in vitro and in ...
Sep 29, 2021
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A clinical trial conducted at UNC Lineberger Comprehensive Cancer Center and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center found that high-dose cytarabine followed by subsequent immunotherapy treatment with pembrolizumab ...
Sep 10, 2021
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Every four minutes, someone in the United States is diagnosed with a type of blood cancer, such as lymphoma or leukemia. According to the American Cancer Society's estimates, approximately 60,530 cases of leukemia and 90,000 ...
Sep 9, 2021
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New research from Edith Cowan University (ECU) has revealed responders to the 9/11 terrorist attacks are still suffering 20 years later, with many facing significant health issues related to the event.
Sep 3, 2021
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