Immunology

Common denominator that triggers asthma in favorable environments

In recent decades, asthma has become a major public health problem. The exponential increase in asthma cases in industrialized countries over the past 50 years is due to major changes in the environment. Among these environmental ...

Medical research

Immune reaction causes organ damage from malaria infection

Malaria is one of the world's deadliest infectious diseases: a small mosquito bite delivers numerous malaria parasites into the bloodstream. The human body defends itself valiantly against the parasite, which usually results ...

Diseases, Conditions, Syndromes

A surprise mechanism uncovered in the development of lupus

In a study with a surprising outcome, scientists at Yale School of Medicine have discovered that an enzyme complex known for promoting natural resistance to bacteria and fungi unexpectedly inhibits the development of lupus. ...

Cardiology

Atherosclerosis: Induced cell death destabilizes plaques

Many chronic disorders arise from misdirected immune responses. A Ludwig-Maximilians-Universitaet (LMU) team led by Oliver Söhnlein now shows that neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death ...

Medical research

Start-stop system of hunting immune cells

Neutrophils belong to the first responders of our immune system. They circulate in our bodies and hunt in infected tissues to ingest, kill, and digest harmful pathogens. To become such effective killers in the very complex ...

Diseases, Conditions, Syndromes

Potential new treatment for kidney failure in cancer patients

Kidney dysfunction is a frequent complication affecting more than 50 percent of all cancer patients, and is directly linked to poor survival. Despite the high occurrence, it is still not clear how presence of a tumour contributes ...

Genetics

Finding genetic ripple effects in a single-cell environment

Although advances in genetics and genomics reveal numerous disease-associated gene mutations associated with disease, physicians and researchers still wrestle with the tricky challenge of linking those mutations to actual ...

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