Engineered enzyme eliminates nicotine addiction in preclinical tests
Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents.
Oct 17, 2018
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Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents.
Oct 17, 2018
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2449
Why do smokers have a five to ten times greater risk of developing alcohol dependence than nonsmokers? Do smokers have a greater tendency toward addiction in general or does nicotine somehow reinforce alcohol consumption?
Apr 14, 2015
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(AP) -- A pill developed in Bulgaria during the Soviet era shows promise for helping millions of smokers cheaply and safely kick the habit, the first big study of it shows.
Sep 28, 2011
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Northwestern scientists have discovered new mechanisms used by nicotine to manipulate the brain's reward pathway—findings which could inform the development of future anti-addiction therapies.
May 31, 2018
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Part of the reason people find smoking difficult to quit is that each time they have a cigarette, feelings of craving, irritability and anxiety melt away. This component of addiction is known as negative reward and is controlled ...
Dec 1, 2015
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The American College of Rheumatology (ACR) and the American Association of Hip and Knee Surgeons (AAHKS) have released a summary of its new guideline titled "the Optimal Timing of Elective Hip or Knee Arthroplasty for Patients ...
Mar 14, 2023
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After decades denying the role of nicotine dependence in smoking addiction, tobacco company Philip Morris (PM) publicly embraced nicotine as the main driver of smoking behavior in 2000. However, their internal understanding ...
May 1, 2018
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Two new studies have found that smokers who tend to take their first cigarette soon after they wake up in the morning may have a higher risk of developing lung and head and neck cancers than smokers who refrain from lighting ...
Aug 8, 2011
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The US Family Smoking Prevention and Tobacco Control Act, passed in 2009, permits the U.S. Food and Drug Administration (FDA) to set standards for cigarette nicotine content. The FDA is accordingly supporting research into ...
Jul 22, 2015
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The use of 'ice' flavored e-cigarettes may be common and positively associated with conventional smoking and nicotine dependence among young adults, suggests research published online in the journal Tobacco Control.
Jun 14, 2021
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Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae) which constitutes approximately 0.6–3.0% of dry weight of tobacco, with biosynthesis taking place in the roots, and accumulating in the leaves. It functions as an antiherbivore chemical with particular specificity to insects; therefore nicotine was widely used as an insecticide in the past, and currently nicotine analogs such as imidacloprid continue to be widely used.
In low concentrations (an average cigarette yields about 1 mg of absorbed nicotine), the substance acts as a stimulant in mammals and is one of the main factors responsible for the dependence-forming properties of tobacco smoking. According to the American Heart Association, "Nicotine addiction has historically been one of the hardest addictions to break." The pharmacological and behavioral characteristics that determine tobacco addiction are similar to those that determine addiction to drugs such as heroin and cocaine. Nicotine content in cigarettes has actually slowly increased over the years, and one study found that there was an average increase of 1.6% per year between the years of 1998 and 2005. This was found for all major market categories of cigarettes.
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