Medical research
A better bone marrow transplant: Preventing graft-versus-host disease
Bone marrow transplant is a key treatment for patients with leukemia, lymphoma, multiple myeloma and other blood disorders.
Mar 1, 2013
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News tagged with notch signaling
Oncology & Cancer
Study may explain why targeted drug doesn't benefit patients with early-stage lung cancer
The drug erlotinib is highly effective in treating advanced-stage lung cancer patients whose tumors have a particular gene change, but when the same drug is used for patients with early-stage tumors with the same gene change, ...
Oct 27, 2014
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Immunology
Paths not taken: Notch signaling pathway keeps immature T cells on the right track
One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development. Notch signaling induces expression of genes that promote the maturation ...
Nov 23, 2013
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Genetics
Controlling cell-fate decisions
Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial ...
Sep 23, 2016
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Medical research
Researchers discover signaling cascade that drives fatty tumors
A common cell signaling pathway that controls differentiation of stem cells may also control the formation of tumor cells in fat, according to a Purdue University study.
Aug 31, 2016
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Oncology & Cancer
From molecular case studies: Genomics of exceptional responder to NOTCH inhibitor
Normal T-cell development requires Notch signaling but hyperactivity can lead to cancer. Drugs that inhibit Notch, such as gamma-secretase inhibitors (GSIs), are currently being tested in different cancer types but clinical ...
Oct 6, 2015
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Immunology
Study in mice shows blocking abnormal stem cell signal during aging lessens related bone loss
A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.
Sep 27, 2023
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Oncology & Cancer
Scientists detail critical role of gene in many lung cancer cases
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown that a well-known cancer-causing gene implicated in a number of malignancies plays a far more critical role in non-small cell lung cancer, ...
Aug 29, 2013
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Medical research
New blood: Tracing the beginnings of hematopoietic stem cells
Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery. In a paper published online this week in Nature, researchers at ...
Aug 14, 2014
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Medical research
The role of Klumpfuss in intestinal cell differentiation
Stem cells are essential for homeostasis and cell renewal in organs like skin, lung or intestine. During the course of life, their function decreases steadily, making this decline a main factor for the development of age-associated ...
Oct 21, 2019
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