A research team—co-led by Penn Nursing—has made a significant breakthrough in understanding the complex neural circuitry underlying reward and addiction by identifying 34 distinct subtypes of medium spiny neurons (MSNs) ...
Aug 14, 2024
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A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological ...
Aug 8, 2024
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Researchers at Western have found an over-the-counter natural health product may help counteract the negative effects of heavy cannabis use among adolescents aged 12 to 17, including depression, anxiety and diminished motivation ...
Jul 29, 2024
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In Huntington's disease, the mutant huntingtin gene (HTT) mRNA is retained in the nucleus and forms insoluble clusters. A new study shows that short interfering RNA (siRNA), an oligonucleotide therapeutic strategy that reduces ...
Jul 22, 2024
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The fluid-filled cushions between the bones in your spine are called disks. They provide flexibility, allow for spine movement like flexion and extension, and act as shock absorbers.
Jul 22, 2024
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Chronic pain affects approximately 20% of the United States population and 30% of the global population. Along with sensory manifestations, chronic pain conditions also are associated with high rates of comorbid depression ...
Jul 11, 2024
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Borstel researchers are the first to develop a biomarker to predict the occurrence of neuropathic adverse events during therapy for multidrug-resistant tuberculosis. The results have now been published in the journal Pathogens ...
Jul 2, 2024
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Adenosine A2A receptors (A2AR) in the nucleus accumbens of the brain play an important role in regulating sleep and motivation, but until now, no drugs have been able to selectively modulate their function without affecting ...
May 23, 2024
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Mutations in the MAGEL2 gene, which cause Schaaf-Yang syndrome (SYS)—an ultra-rare disease that affects neuronal and cognitive development—generate truncated, non-functional proteins that tend to accumulate in the cell ...
May 7, 2024
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Today, neurostimulation is used to treat a variety of human disorders, including Parkinson's disease, tremor, obsessive-compulsive disorder and Tourette syndrome. A Mayo Clinic neurosurgeon and his colleagues believe one ...
Mar 15, 2024
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