Intranasal (in.) administration has been garnering increasing popularity as a non-invasive approach to deliver drugs directly to the brain. This approach involves the respiratory or olfactory epithelia of the nasal mucosa ...
Nov 11, 2022
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A review of studies about the effect of SARS-CoV-2—the virus that causes COVID-19—on the olfactory system introduces questions about whether loss of smell associated with COVID-19 infection may increase the risk of developing ...
Aug 2, 2022
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A number of studies have shown that human coronaviruses, including SARS-CoV-2 which causes COVID-19, appear to attack neurons and the nervous system in vulnerable populations. This neuroinvasion through the nasal cavity leads ...
Mar 23, 2021
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Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimer's disease (AD) and appears in approximately 90% of all patients. While loss of smell is a major symptom, patients with AD are ...
Feb 25, 2021
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The loss of a sense of smell is known to be one of the earliest signs of Parkinson's disease (PD) and can even appear years before the characteristic tremors and loss of motor function are seen. Some scientists believe that ...
Aug 3, 2020
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From the first reports coming out of Wuhan, Iran and later Italy, we knew that losing your sense of smell (anosmia) was a significant symptom of the disease. Now, after months of reports, both anecdotal and more rigorous ...
Jun 19, 2020
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"… I carried to my lips a spoonful of the tea in which I had let soften a bit of madeleine. But at the very instant when the mouthful of tea mixed with cake crumbs touched my palate, I quivered, attentive to the extraordinary ...
Mar 3, 2020
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Mammals have an exquisitely tuned sensory system that tells them whether they are smelling an orange or a rose. Like keys on a piano keyboard, each component of an odor blend strikes only one chord of olfactory neuron activation. ...
May 26, 2016
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Penn Medicine researchers are continuing their work in trying to understand the mechanisms through which anesthetics work to elicit the response that puts millions of Americans to sleep for surgeries each day. Their most ...
Apr 1, 2015
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What we view as the sense of taste is actually a combination of smell, taste and texture, with smell playing a major role. A single taste bud can have dozens of receptor cells that send signals of sour, sweet, salty and bitter ...
Feb 23, 2015
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