Neuroscience

Cocaine addiction traced to increase in number of orexin neurons

A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin—a chemical messenger important for sleep and appetite—that may be at the root of the addiction. The study, performed ...

Alzheimer's disease & dementia

Dysregulation in orexinergic system associated with Alzheimer disease

In patients with Alzheimer disease (AD), increased cerebrospinal fluid levels of orexin, which helps regulate the sleep-wake cycle, may be associated with sleep deterioration, which appears to be associated with cognitive ...

Neuroscience

Sleep-deprived mice find cocaine more rewarding

Sleep deprivation may pave the way to cocaine addiction. Too-little sleep can increase the rewarding properties of cocaine, according to new research in mice published in eNeuro.

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