New research shows that microRNA-486 is a potent tumor-suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung-cancer cells, and the induction of programmed cell death, or ...
Sep 16, 2013
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About half of all cancer patients have a mutation in a gene called p53, which allows tumors to survive and continue growing even after chemotherapy severely damages their DNA.
Nov 14, 2013
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Rare inherited mutations in the body's master regulator of the DNA repair system—the TP53 gene—can leave people at a higher risk of developing multiple types of cancer over the course of their lives. Now, for the first ...
Jul 16, 2020
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When it comes to genes associated with cancer, none have been studied more extensively than p53, a tumor suppressor gene that serves as the guardian of our genetic information. More than half of all cancers have mutations ...
Jan 15, 2016
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Cholesterol-lowering statins seem to keep breast cancer at bay in some patients. Now researchers reporting in the January 20th issue of the journal Cell, a Cell Press publication, provide clues about how statins might yield ...
Jan 19, 2012
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It doesn't often happen that army generals switch sides in the middle of a war, but when cancer's attack is underway, it may even cause a gene that acts as the body's master defender to change allegiance. As reported recently ...
Jul 25, 2018
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New findings by Fox Chase Cancer Center researchers link a common variant of the powerful anticancer gene p53 to increased inflammatory responses following DNA damage. The results may help explain why African Americans, ...
Apr 4, 2011
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Moffitt Cancer Center researchers have developed a new method to identify a previously unknown structure in a protein called MDMX. MDMX is a crucial regulatory protein that controls p53 - one of the most commonly mutated ...
Apr 13, 2015
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Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply can be fatal ...
Apr 15, 2013
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Proteins that are frequently altered in tumors play a prominent role in cancer research. The protein RFX7, a largely unknown transcription factor, has recently been linked to lymph node cancer. Researchers at the Leibniz ...
Jul 19, 2022
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