In Type 1 diabetes the immune system mistakenly attacks and destroys insulin-producing pancreatic cells, leaving patients dependent on lifelong insulin injections. The putative perpetrators of the attack—which are called ...
Mar 23, 2018
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Type 2 diabetes, which affects >0.5 billion people worldwide, results from the inability of beta cells in the pancreatic islets to provide the body with enough insulin to maintain blood glucose levels within the range for ...
Nov 30, 2017
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Over the past 15 years, University of Alabama at Birmingham endocrinologist Anath Shalev, M.D., has unraveled a crucial biological pathway that malfunctions in diabetes.
Nov 7, 2017
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Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion. But researchers from the University of North Carolina ...
Oct 30, 2017
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Together with colleagues from AP-HP Necker–Enfants Malades Hospital in Paris, scientists from the Cochin Institute (CNRS / INSERM / Paris Descartes University) have discovered that the onset of type 1 diabetes is preceded ...
Oct 10, 2017
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Tight regulation of calcium levels in the endoplasmic reticulum (ER) – a cellular organelle with multiple functions – contributes to insulin secretion by pancreatic beta cells. Although ER calcium handling is perturbed ...
Sep 29, 2017
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Investigators in the Vanderbilt Diabetes Research and Training Center (VDRTC) and collaborators at Stanford University have discovered new insights into the molecular mechanisms of cell proliferation in juvenile human pancreatic ...
Sep 22, 2017
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Researchers from the Johns Hopkins University School of Medicine, Stanford University and the University of Florida report the development of a novel antibody detection technology that holds promise for improving the accuracy ...
Sep 13, 2017
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(HealthDay)—Cytokines and chemokines produced by pancreatic islets in response to inflammatory and metabolic stress include interferon gamma-induced protein 10 (IP-10/CXCL10), which is associated with poor islet transplant ...
Sep 7, 2017
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In the destructive cycle that leads to and perpetuates type 2 diabetes, driven by overeating, excessive blood glucose, defective pancreatic beta cell function, and imbalances in insulin-regulating hormone levels, the gut ...
Aug 3, 2017
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