Paracetamol versus ibuprofen—which works best and when?
In most cases, pain and fever relief is as simple as a trip to your local supermarket for some paracetamol or ibuprofen.
Jun 27, 2023
0
4
In most cases, pain and fever relief is as simple as a trip to your local supermarket for some paracetamol or ibuprofen.
Jun 27, 2023
0
4
Acute low back pain is a common cause of disability. An analysis in the Journal of Orthopaedic Research examined which non-opioid drugs are best for treating this condition.
Feb 22, 2023
0
16
Paracetamol is Australia's most widely used pain medicine, with 65 million packs sold across the country in 2021. It is available everywhere from toilet vending machines, convenience stores, supermarkets, and pharmacies.
Sep 29, 2022
0
9
Paracetamol is used in many illnesses for the relief of pain and fever, but a study just published in Clinical Infectious Diseases has shown that it may also help protect against kidney damage in patients with malaria.
Mar 3, 2022
0
52
Doctors have warned that people should try to avoid taking dissolving, fizzy paracetamol that contains salt, following findings from a large study that shows a link with a significantly increased risk of heart attacks, stroke, ...
Feb 24, 2022
0
2
Long-term paracetamol use could increase the risk of heart disease and strokes in people with high blood pressure, a study suggests.
Feb 7, 2022
0
55
An epidemiological study of more than 70,000 children in six European cohorts has linked symptoms of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum conditions (ASC) to the mothers' use of paracetamol ...
May 28, 2021
0
12
The combination of a high-dose NSAID with paracetamol does not increase the analgesic effect compared to paracetamol alone. Researchers also found that paracetamol alone is superior to high-dose NSAID alone for posttraumatic ...
Feb 9, 2021
0
0
Paracetamol is a popular source of pain relief. In Switzerland, it is available over the counter in 500 milligram tablets, but also in 1,000 milligram (1 gram) tablets when prescribed by a physician. Researchers at ETH Zurich ...
Oct 28, 2020
0
70
New research has found a mechanism that suggests that some fetuses and newborns exposed to paracetamol may experience untoward effects. The experimental approach used is now being applied to other drugs that may be taken ...
Sep 30, 2020
0
5
Paracetamol INN ( /ˌpærəˈsiːtəmɒl/ or /ˌpærəˈsɛtəmɒl/), or acetaminophen USAN i/əˌsiːtəˈmɪnəfɨn/, is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post surgical pain and providing palliative care in advanced cancer patients. The onset of analgesia is approximately 11 minutes after oral administration of paracetamol, and its half-life is 1–4 hours.
While generally safe for use at recommended doses (1,000 mg per single dose and up to 3,000 mg per day for adults, up to 2,000 mg per day if drinking alcohol), acute overdoses of paracetamol can cause potentially fatal liver damage and, in rare individuals, a normal dose can do the same; the risk is heightened by alcohol consumption. Paracetamol toxicity is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia and New Zealand.
It is the active metabolite of phenacetin, once popular as an analgesic and antipyretic in its own right, but unlike phenacetin and its combinations, paracetamol is not considered to be carcinogenic at therapeutic doses. The words acetaminophen (used in the United States, Canada, Japan, South Korea, Hong Kong, and Iran) and paracetamol (used elsewhere) both come from chemical names for the compound: para-acetylaminophenol and para-acetylaminophenol. In some contexts, it is simply abbreviated as APAP, for acetyl-para-aminophenol.
This text uses material from Wikipedia, licensed under CC BY-SA