Neuroscience

New approach enables a closer look at microglial organelles

Microglia are the immune system's front-line enforcers in the brain. They are cells that patrol the brain and destroy anything harmful that they encounter, from invading bacteria to cellular debris. They also remove plaques ...

Medical research

Exploring how fungal spores hijack lung cells

The pathogenic fungus Aspergillus fumigatus escapes elimination from surface cells of the human lung by binding to a human protein. In doing so, it is able to nest in so called phagosomes, confined areas in the lung cells, ...

Immunology

How immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf foreign objects that cross their way. After enclosing them in intracellular membrane vesicles, a process ...

Diseases, Conditions, Syndromes

A defence mechanism that can trap and kill TB bacteria

A natural mechanism by which our cells kill the bacterium responsible for tuberculosis (TB) has been discovered by scientists at the Francis Crick Institute, which could help in the battle against antibiotic-resistant bacteria.