Genetics

Study links gene mutation to learning deficits in 'Clueless' mice

A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS. The novel mutation decreases the activity of neurons ...

Medications

Study sheds new light on a promising antidepressant

Ketamine, a well-known anesthetic used in smaller doses as a party drug, was hailed as a "new hope for depression" in a Time magazine cover story in 2017. Two years later, the arrival of the first ketamine-based antidepressant—the ...

Biomedical technology

'Smart' diaper for bedside urine testing

Urine can reveal a lot about a person's health. But physicians don't currently have a convenient or fast way of tracking the concentration of important compounds in their patients' urine. Now, researchers reporting in ACS ...

Genetics

Potassium channel dysfunction in genetic epilepsy

Northwestern Medicine scientists have discovered functional links between dozens of potassium channel gene variants and neonatal epilepsy, according to a study published in JCI Insight.

Genetics

A 'pump' gene's surprising role in early brain formation

In polymicrogyria, the cortex of the brain has many irregular, small folds (gyria) and disorganization of its layers. Many affected children have severe developmental delay, intellectual disabilities, and epilepsy, and many ...

Medical research

Worms reveal why melatonin promotes sleep

Melatonin is used as a dietary supplement to promote sleep and get over jet lag, but nobody really understands how it works in the brain. Now, researchers at UConn Health show that melatonin helps worms sleep, too, and they ...

Neuroscience

New drug reduces stroke damage in mice

Neuroscientists at the University of Pittsburgh Brain Institute have identified a novel drug that could protect the brain during and after a stroke.

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