Identifying genetic risk factors for Alzheimer's disease is essential if we are to improve our understanding and treatment of it. Progress in human genome analysis along with genome-wide association studies are now leading ...
Apr 4, 2022
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84
Researchers have identified amyloid beta (Aβ) detected in blood to originate from peripheral tissues, and that the peptide acts on pancreaticβ-cells to suppress insulin secretion, thereby regulating blood glucose levels. ...
Mar 15, 2022
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103
Researchers from the Université Laval Faculty of Medicine and CHU de Québec–Université Laval Research Center have successfully edited the genome of human cells grown in vitro to introduce a mutation providing protection ...
Feb 10, 2022
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912
Down syndrome is mostly known for the learning disabilities it causes, but patients typically suffer from a wide number of ailments. One is the early onset of Alzheimer's disease. Using iPS cells from Down syndrome patients, ...
Sep 1, 2021
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39
Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system. Apart from dynamic ...
Aug 18, 2021
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224
University of California, Irvine biologists have developed a new genetically engineered mouse model, that unlike its predecessors, is based on the most common form of Alzheimer's disease. The advance holds promise for making ...
Apr 27, 2021
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50
One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. ...
Apr 15, 2021
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230
A gene has been discovered that can naturally suppress the signs of Alzheimer's Disease in human brain cells, in research led by Queen Mary University of London. The scientists have also developed a new rapid drug-screening ...
Jul 9, 2020
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1214
A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer's disease. As published ...
Feb 3, 2020
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105
The amyloid precursor protein has always been vilified as a major cause of Alzheimer's disease. One of its fragments, the amyloid-beta peptide, can break off and accumulate in the brain, giving rise to the puffy white globs ...
Jun 14, 2019
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409
