Diseases, Conditions, Syndromes

SARS-CoV-2 protein caught severing critical immunity pathway

Over the past two years, scientists have studied the SARS-CoV-2 virus in great detail, laying the foundation for developing COVID-19 vaccines and antiviral treatments. Now, for the first time, scientists at the Department ...

Oncology & Cancer

How the immune system becomes blind to cancer cells

T cells play a huge role in our immune system's fight against modified cells in the body that can develop into cancer. Phagocytes and B cells identify changes in these cells and activate the T cells, which then start a full-blown ...

Medical research

Activation of opioid receptor uncovered

Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor. The results facilitate the development of new ...

Diabetes

Researchers identify trigger and mechanism in type 1 diabetes

Researchers at National Jewish Health have identified an elusive trigger of type 1 diabetes. A protein fragment formed in the pancreas activates the immune system's T cells, leading them to attack and destroy beta cells, ...

Parkinson's & Movement disorders

How disease mutations affect the Parkin protein

Researchers at the MRC Laboratory of Molecular Biology in the United Kingdom have determined the crystal structure of Parkin, a protein found in cells that when mutated can lead to a hereditary form of Parkinson's disease. ...

Medical research

In the pursuit of dangerous clumps

When normal proteins form protein clumps in the body, then alarm bells start ringing. Such clumps, called "amyloids," are closely associated with Alzheimer's disease and type 2 diabetes, formerly called adult-onset diabetes. ...

Medical research

Model of enigmatic Alzheimer's protein described for first time

Yale School of Medicine researchers have described for the first time the structure of a member in an enigmatic family of proteins linked to Alzheimer's disease, a crucial early step in understanding key mechanisms of the ...

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