Oncology & Cancer

Protein loss promotes cell migration

The protein STK17A (serine threonine kinase 17A) appears to play roles in various cancer types. It can be oncogenic or tumor suppressive, depending on the cancer, but its role in colorectal cancer has not been established.

Oncology & Cancer

Study identifies strategy to avoid resistance to cancer therapy

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death. A study led by the Protein Kinases ...

Oncology & Cancer

Alternative target for breast cancer drugs

Scientists have identified higher levels of a receptor protein found on the surface of human breast tumour cells that may serve as a new drug target for the treatment of breast cancer. The results, which are published today ...

Oncology & Cancer

Hedgehog pathway key in tamoxifen-resistant breast CA

(HealthDay)—Noncanonical Hedgehog (Hh) signaling is activated in tamoxifen-resistant tumors, and the phosphoinositide 3-kinase inhibitor/protein kinase B (PI3K/AKT) pathway plays a key role protecting Hh signaling molecules, ...

Medical research

Putting the squeeze on red blood cells

For the first time, researchers at the University of Bristol's Blood and Transplant Research Unit, and the French National Institute for Blood Transfusion, have captured the moment a red blood cell is "squeezed" while recording ...

Medical research

Molecule acts as umpire to make tough life-or-death calls

Researchers have demonstrated that an enzyme required for animal survival after birth functions like an umpire, making the tough calls required for a balanced response to signals that determine if cells live or die. St. Jude ...

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