The role of FIH-1 in the regulation of HIF-1 transcriptional activity has been known for some time, but is limited to the understanding that in the nucleus FIH-1 hydrolyzes asparagine at the C-terminus of HIF-1α to prevent ...
Oct 31, 2015
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Researchers at Nanjing University, China, found new epigenetic markers for colorectal cancer which may offer a new approach for treatment.
Sep 11, 2015
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Small chemical changes in the DNA building blocks, which may be influenced by lifestyle factors, can reduce the amount of IGFBP2. A DIfE / DZD research team has now reported in the journal Diabetes that these epigenetic changes ...
Nov 9, 2018
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A recent collaborative research endeavor, published in Cell Reports Medicine, highlights a promising therapeutic avenue for amyotrophic lateral sclerosis (ALS). Led by researchers from Ben-Gurion University of the Negev in ...
May 29, 2024
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Physician–scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have uncovered significant findings regarding the impact of transthyretin, or TTR, protein levels on heart disease ...
Jul 29, 2024
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Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to Whitehead Institute researchers. In mouse models of cancer, ...
Jul 18, 2013
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Researchers at Albert Einstein College of Medicine of Yeshiva University in collaboration with Nurses' Health Study investigators have shown that levels of certain related proteins found in blood are associated with a greatly ...
May 3, 2012
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Researchers from the University of North Carolina School of Medicine have discovered that a well-known associate of G protein-coupled receptors—a common target of FDA-approved drugs—may play a critical role in mounting ...
Aug 16, 2013
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Neurodegenerative diseases such as Alzheimer's could be better understood thanks to insight into proteins linked to such conditions, a study suggests.
Jul 2, 2013
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Amyloid diseases, including Alzheimer's, Parkinson's, type-2 diabetes and other life-threatening diseases, involve pathologic deposits of normally soluble proteins or peptides as insoluble amyloid fibrils. When this happens ...
Jun 28, 2021
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