Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. For decades, scientists have attempted to develop drugs that selectively activate one type of opioid receptor ...
May 3, 2023
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71
Many patients with the autoimmune disease ANCA-associated vasculitis (AAV) suffer a high risk of disease relapse despite treatment. Karolinska Institutet researchers have now identified T cells that contribute to the destruction ...
Feb 16, 2023
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38
In animals, a process of programmed cell death called apoptosis ensures cells die when they should. An opposing force, governed by inhibitor of apoptosis proteins (IAPs), guards against excessive cell death. Together these ...
Feb 9, 2023
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Hitting two targets at the same time may be the key to stopping the spread of aggressive cancers, according to new research from the University of East Anglia and the Quadram Institute.
Dec 12, 2022
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20
Sodium may hold the key for scientists to develop opioids or other drugs with far fewer side effects.
Nov 30, 2022
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46
Northwestern Medicine scientists have discovered the pathways through which autoantibodies—immune proteins that mistakenly attack a person's own body—leak out of blood vessels and cause primary graft dysfunction in some ...
Nov 18, 2022
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12
Most COVID-19 therapeutics target the SARS-CoV-2 proteins. Because the viral proteins acquire genetic sequence mutations, the emergence of new variants has a risk to make the drugs ineffective.
Oct 31, 2022
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After decades of research and two previous drug development attempts, things are looking promising for a team of University of Arizona researchers working on a less toxic treatment for a specific type of breast cancer.
Oct 25, 2022
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94
Wear and tear on joints can lead to inflammation, breakdown of cartilage and development of osteoarthritis. Scientists at UF Scripps Biomedical Research have found a possible new target to fight this painful cascade.
Oct 14, 2022
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New research has revealed how the tau protein, a critical element in the formation of Alzheimer's disease, is also involved in normal learning processes in the healthy brain—potentially providing a focal point for future ...
Aug 23, 2022
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22
