Neuroscience
Small proteins help deliver receptors to the surface of our cells, ensuring their function
Receptors on the surface of our cells enable a wide variety of functions from our sense of smell to memory.
Jan 24, 2017
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News tagged with protein-coupled receptors
Oncology & Cancer
Unmasking previously misunderstood gene, scientists discover potential drug target for gastrointestinal cancers
Like a bank robber on the lam, Gpr182 had assumed a variety of identities over several decades: G10D, HrhAMR, Gamrh, 7TMR, ADMR. Unable to put a finger on what exactly the gene does, scientists largely left it alone. The ...
Jan 20, 2017
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Neuroscience
Cannabinoid receptor activates spermatozoa
Biologists from Bochum and Bonn have detected a cannabinoid receptor in spermatozoa. Endogenous cannabinoids that occur in both the male and the female genital tract activate the spermatozoa: they trigger the so-called acrosome ...
Aug 30, 2016
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Medical research
Could suppression of Gαq/11 signaling be a promising target for treating bone loss?
Intermittent parathyroid hormone treatment (iPTH) and mechanical loading through exercise have both been shown to stimulate bone formation. These osteoanabolic stimuli are partially mediated by G protein-coupled receptors. ...
Aug 9, 2016
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Health
Do artificial sweeteners live up to the promise of sweetness without harm?
There was a time when Thomas Huber, a molecular biologist at The Rockefeller University, was drinking about 36 ounces of diet cola a day. More than a year ago, Huber, a research assistant professor in Thomas P. Sakmar's Laboratory ...
Jun 3, 2016
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Medical research
Researchers identify important signaling molecule
An international team of scientists have provided insights into the working of a "signaling molecule", which will provide new strategies for medicines in areas such as pain medication.
Mar 25, 2016
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Medical research
Researchers shed pharmacological light on formerly 'dark' cellular receptors
Our cells are constantly communicating, using neurotransmitters and hormones to signal to each other. Molecular receptors on each cell receive these chemical signals and allow cells to accomplish a task important for health. ...
Nov 9, 2015
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Medical research
Familiar drugs may block Ebola virus infection
A well-known class of molecules, many of which are already in use therapeutically, may be able to block the Ebola virus's entry into cells and halt the disease in its tracks, according to researchers at the University of ...
Aug 7, 2015
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Medical research
Crystal clear images uncover secrets of hormone receptors
Many hormones and neurotransmitters work by binding to receptors on a cell's exterior surface. This activates receptors causing them to twist, turn and spark chemical reactions inside cells. NIH scientists used atomic level ...
Jul 31, 2015
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Medical research
Mechanism behind the lack of effectiveness of certain antagonist drugs discovered
Researchers have published a study in the journal Proceedings of the National Academy of Sciences (PNAS) about the formation of G protein-coupled receptors (GPCRs) which allows understanding the unexpected behaviour of some ...
Jul 29, 2015
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