Medical research

Psoriasis: Towards a novel therapeutic approach

Psoriasis is a frequent skin inflammatory disorder affecting 3% of the population. Psoriasis is characterized by hyperproliferation and defect of epidermal differentiation, leading to the scaly appearance of the skin. Psoriatic ...

Inflammatory disorders

Inflammation linked to thyroid dysfunction in psoriasis patients

(HealthDay)—While the rate of thyroid dysfunction among patients with psoriasis generally is not higher than expected, psoriasis in patients with thyroid dysfunction is more clinically severe and serum levels of C-reactive ...

Diseases, Conditions, Syndromes

Insights into psoriasis suggest a new treatment target

Psoriasis is a skin disorder that affects at least 100 million individuals worldwide. Its economic impact is more than $10 billion annually in the U.S. alone. Involved skin becomes thickened, red, and covered with silvery ...

Diseases, Conditions, Syndromes

Palmoplantar pustulosis confirmed as orphan disease

(HealthDay)—Co-occurring psoriasis is common among patients with palmoplantar pustulosis (PPP), according to a study published in the November issue of the British Journal of Dermatology.

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Psoriasis

Psoriasis (pronounced /səˈraɪəsɪs/) is a chronic, non-contagious autoimmune disease which affects the skin and joints. It commonly causes red scaly patches to appear on the skin. The scaly patches caused by psoriasis, called psoriatic plaques, are areas of inflammation and excessive skin production. Skin rapidly accumulates at these sites and takes on a silvery-white appearance. Plaques frequently occur on the skin of the elbows and knees, but can affect any area including the scalp and genitals. In contrast to eczema, psoriasis is more likely to be found on the extensor aspect of the joint.

The disorder is a chronic recurring condition which varies in severity from minor localized patches to complete body coverage. Fingernails and toenails are frequently affected (psoriatic nail dystrophy) and can be seen as an isolated finding. Psoriasis can also cause inflammation of the joints, which is known as psoriatic arthritis. Ten to fifteen percent of people with psoriasis have psoriatic arthritis.

The cause of psoriasis is not known, but it is believed to have a genetic component. Factors that may aggravate psoriasis include stress, withdrawal of systemic corticosteroid, excessive alcohol consumption, and smoking. There are many treatments available, but because of its chronic recurrent nature psoriasis is a challenge to treat.

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