Oncology & Cancer

New strategy to reduce cancer drug's cardiotoxic effects

Doxorubicin (Doxo) is a widely used chemotherapeutic drug for cancer, though it can have toxic effects on the heart. A recent animal study published in The FASEB Journal investigated whether the cardioregulatory protein chromogranin ...

Psychology & Psychiatry

Menstrual cycle phase influences cocaine craving

Menstrual cycle may influence addiction risk in women, according to a new study in Biological Psychiatry by researchers at the National Institute on Drug Abuse and University of Maryland School of Medicine. In female rats, ...

Health

Binge drinking during youth may impact future offspring

A rat model found preconception binge drinking may have negative consequences on future offspring's growth, social interactions and pubertal development, according to a new study published in the Endocrine Society's Journal ...

Neuroscience

Stress regulates self-harm in rats

A stress hormone modulates compulsive biting in a rat model of self-injurious behavior (SIB), according to new research published in JNeurosci. Manipulating the activity of the brain circuitry underlying SIB could create ...

Neuroscience

Unexpected discovery gives new model for studying brain networks

The same kind of neurons can have completely different wiring diagrams in the rat and mouse, as mice lack intercellular molecular channels known as gap junctions, researchers at Karolinska Institutet report in the scientific ...

Alzheimer's disease & dementia

New tools could uncover important answers for Alzheimer's researchers

Alzheimer's disease currently affects more than 5.5 million Americans and is one of the costliest diseases to treat, according to the Alzheimer's Association. Characterized by a buildup of plaque in the brain, few animal ...

Diseases, Conditions, Syndromes

New compound stops progressive kidney disease in its tracks

Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed. Reporting today in Science, ...

Neuroscience

Realistic rodent model of drug addiction

Drug addiction may not require a habitual relationship with a substance, suggests findings from a new model of cocaine administration in rats that better captures the human experience of obtaining and using drugs. The research, ...

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