A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly aggressive form of ...
Feb 8, 2016
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Understanding Li–Fraumeni syndrome (LFS)—a genetic disorder that substantially increases the risk of a young person developing cancer such as the bone cancer osteosarcoma—is a first step to improving diagnosis and counseling.
Jan 27, 2016
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A deadly form of T cell lymphoma is caused by an unusually large number gene deletions, making it distinct among cancers, a new Yale School of Medicine study shows.
Jul 21, 2015
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A blood test to regularly monitor for the presence of rearrangement of the EML4-ALK gene fusion in patients with non-small cell lung cancer (NSCLC) may help clinicians predict the outcome of treatment with crizotinib, according ...
Apr 20, 2015
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The St. Jude Children's Research Hospital—Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement ...
Mar 6, 2015
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Researchers have found that pancreatic cancer can be split into four unique types, a discovery that could be used to improve treatments for the disease, according to a study published in Nature.
Feb 27, 2015
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Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy ...
Jan 29, 2015
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In 1982, the gene TRK was shown to cause a small percentage of colon cancers. In 2013 and 2014, next-generation sequencing of tumor samples found fusions of the TRK family of genes in at least 11 tumor types, including lung, ...
Dec 29, 2014
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One of the deadliest forms of paediatric brain tumour, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. ...
Jun 23, 2014
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(Medical Xpress)—Patients with lung cancer who also have a specific gene rearrangement do better on a new targeted therapy compared with standard chemotherapy, according a study by University of Manchester scientists.
Jan 13, 2014
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