A new editorial paper titled "Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer?" has been published in Oncotarget.
Aug 21, 2023
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Mesomelic dysplasias are a group of rare genetic conditions characterized by extreme shortening of the long bones in the arms and legs. Despite several decades of research on these conditions, the exact cause of mesomelic ...
Aug 23, 2021
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Crizotinib is effective in shrinking tumors in patients with anaplastic lymphoma receptor tyrosine kinase (ALK) positive non-small cell lung cancer, a cancer commonly found in people who never smoked, and should be the standard ...
Sep 6, 2012
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A blood test to regularly monitor for the presence of rearrangement of the EML4-ALK gene fusion in patients with non-small cell lung cancer (NSCLC) may help clinicians predict the outcome of treatment with crizotinib, according ...
Apr 20, 2015
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An international team of scientists has uncovered one of the mechanisms explaining how some leukemias evade treatment by changing their appearance and identity.
Oct 31, 2022
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A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly aggressive form of ...
Feb 8, 2016
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An international team of researchers from the St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (PCGP) has completed a detailed map of the genomic landscape for core-binding factor ...
Oct 31, 2016
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(Medical Xpress)—Patients with lung cancer who also have a specific gene rearrangement do better on a new targeted therapy compared with standard chemotherapy, according a study by University of Manchester scientists.
Jan 13, 2014
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Mesothelioma is a rare and aggressive tumor that, in many cases, results from exposure to asbestos. But over the last several decades, other causes of the disease have emerged, including treatment with high-intensity therapeutic ...
Sep 14, 2017
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One of the deadliest forms of paediatric brain tumour, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. ...
Jun 23, 2014
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