UT Southwestern researchers report the first structural confirmation that endogenous—or self-made—molecules can set off innate immunity in mammals via a pair of immune cell proteins called the TLR4/MD-2 receptor complex. ...
Jul 22, 2021
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Researchers at the Hebrew University of Jerusalem, in collaboration with researchers at the Salk Institute in California, have found for the first time that a specific protein is essential not only for maintaining a healthy ...
Jan 7, 2013
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The most powerful analgesic and addictive properties of opiate alkaloids are mediated by the m-opioid receptor (mOR). As the receptor primarily responsible for the effects of opium, the mOR is one of the oldest drug targets ...
Aug 6, 2015
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In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone (DHT). For this to happen, these hormones have to bind to androgen ...
Jul 19, 2018
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(Medical Xpress)—Johns Hopkins researchers have used a small synthetic molecule to stimulate cells to move and change shape, bypassing the cells' usual way of sensing and responding to their environment. The experiment ...
Dec 5, 2012
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Researchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer—one of the least understood groups of breast cancer. These molecules, called ...
Apr 9, 2013
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B cells can generate different 'classes' of antibodies, each of which carries a specific type of protein chain that triggers a specific downstream cascade of immune responses. Immunoglobulin M (IgM) antibodies, which are ...
Feb 1, 2013
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Researchers at Sanford-Burnham Medical Research Institute have determined the complete three-dimensional structure of a protein called HNF-4α. HNF-4α controls gene expression in the liver and pancreas, switching genes on ...
Mar 13, 2013
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Scientists have for the first time revealed the structure surrounding important receptors in the brain's hippocampus, the seat of memory and learning.
May 12, 2021
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Researchers at the Monell Center and collaborators have identified a protein that is critical to the ability of mammals to smell. Mice engineered to be lacking the Ggamma13 protein in their olfactory receptors were functionally ...
May 6, 2013
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