Oncology & Cancer

Receptor structure reveals new targets for cancer treatment

A molecule known as anaplastic lymphoma kinase (ALK) is a driver of several cancers, including pediatric neuroblastoma, B-cell lymphomas, and myofibroblast tumors. But for years much about this molecule—its role in the ...

Neuroscience

Findings reveal new mechanism of activation for ALK

ALK is a receptor tyrosine kinase that regulates important functions in the central nervous system. Scientists at St. Jude Children's Research Hospital have used leading-edge structural biology techniques to reveal in more ...

Medications

Search for safer pain relief advances with new compounds

Scientists at Scripps Research in Florida have created a collection of new pain-relieving compounds, that like morphine and other drugs, provide relief via activation of opioid receptors, but without inducing many dangerous ...

Neuroscience

Excitatory neural receptors aid development of adult-born neurons

A unique interaction between an excitatory neural receptor and a chloride transporter are critical for development of adult-born neurons in the dentate gyrus, according to a Northwestern Medicine study published in Cell Reports.

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