Our genomes help to determine who we are - the countless variations between individuals that encode the complexity of tissues and functions throughout the body. Since scientists first decoded a draft of the human genome more ...
Oct 13, 2017
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Nearly half of the human genome is composed of transposable elements, which are sequences of DNA that are able to replicate and relocate in the genome. Previously, transposable elements have been considered "junk" DNA in ...
Oct 2, 2023
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Using an innovative algorithm that analyzes gene regulatory and signaling networks, Columbia University Medical Center (CUMC) researchers have found that loss of a gene called KLHL9 is the driving force behind the most aggressive ...
Oct 9, 2014
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A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the process by which genes ...
May 14, 2024
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A study published in Briefings in Functional Genomics investigated how epigenetics can modulate human's genetic program—it can emphasize or silence genes. The new research shows that if epigenetics is disrupted, it might ...
Mar 24, 2017
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In the process of metastasis, the movement of cancer cells to different parts of the body, a specific master regulator gene plays a central role: a transcription factor named Sox4 activates a sequence of genes and triggers ...
Jun 10, 2013
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Older age at the time of conception and alcohol consumption during pregnancy have long been known to impact fetal development.
Mar 17, 2021
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A UT Southwestern Medical Center researcher has identified the most comprehensive measurement to date of estrogen's effect on breast cancer cells, showing for the first time how immediate and extensive the effect is.
May 5, 2011
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Mammalian cells seem to be able to memorize anti-viral stimulation at the level of DNA-packaging molecules, enabling faster and greater activation of anti-viral genes in subsequent stimulations, according to a study conducted ...
Oct 25, 2018
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How do individual developing cells choose and commit to their "identity"—to become, for example, an immune cell, or a muscle cell, or a neuron?
Nov 19, 2018
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