Professor Yi Sun's team at the Zhejiang University report a functional compensatory effect between the Ube2m-Rbx1 and Ube2f-Sag axes of the neddylation–Cullin-RING ligases (CRLs) system in Treg cells, using conditional ...
Dec 22, 2023
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A highly aggressive common form of leukemia which is activated by mutations in signaling molecules is maintained by a web of regulatory proteins downstream of these signals.
Dec 20, 2023
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A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, ...
Dec 6, 2023
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While stem cell therapy has been used to successfully generate and repair tissues that have been damaged due to certain conditions and diseases, such as leukemia, it is far from a cure-all.
Nov 30, 2023
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Scientists at St. Jude Children's Research Hospital described the gene regulatory networks contributing to differences between subtypes of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The work examined ...
Nov 20, 2023
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A subtype of CD8 T cells, which are classically known to promote immune system responses, may be in fact regulating the immune system by suppressing immune cells causing self-destructive responses leading to autoimmune disorders ...
Nov 15, 2023
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Regulatory T cells are specialized immune cells that suppress the immune response and prevent the body from attacking its own cells. Understanding how these cells work is key to determining how they might be manipulated to ...
Nov 6, 2023
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The immune system is fast when it comes to fighting viruses, bacteria and other pathogens. But it also has to know when not to attack—for example, harmless substances such as pollen or house dust, which otherwise trigger ...
Oct 30, 2023
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Severe combined immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development. SCID can also affect B-cell and natural killer ...
Oct 27, 2023
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Liver cancer is the fourth deadliest cancer in Hawaiʻi, particularly affecting Native Hawaiian, Filipino and Japanese men. Patients can develop liver failure when tumors metastasize or spread to the healthy portions of the ...
Oct 26, 2023
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