The protein mTOR is a central controller of growth and metabolism. Deregulation of mTOR signaling increases the risk of developing metabolic diseases such as diabetes, obesity and cancer. In the current issue of the journal ...
Aug 11, 2014
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St. Jude Children's Research Hospital scientists have mapped the structural details of how p53 attaches to its regulatory protein, called BCL-xL, in the cell. The protein p53 is a key activator of the cell's protective machinery ...
May 15, 2014
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People with mutations in a gene called BSCL2 suffer from a rare medical condition known as lipodystrophy in which fat tissue is lost from where it is supposed to accumulate while being deposited at unusual sites around the ...
Feb 12, 2014
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(Medical Xpress)—A small molecule developed at Yale University to limit damage done by ischemia – restricted blood flow – during heart attacks or surgery has been shown to reduce by 40 percent the amount of heart muscle ...
Sep 5, 2013
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The hepatitis C virus hijacks the body's immune system, leaving T cells unable to function. A new study in animal models suggests that blocking a protein that helps the virus thrive could restore immune function, allowing ...
Sep 3, 2013
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During formation of the vascular system, successively smaller blood vessels sprout from existing ones to form networks of capillaries in patterns uniquely adapted to the function of the organ they enter. This process, called ...
Aug 30, 2013
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Scientists at A*STAR's Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons. This important finding, which is crucial in understanding serious diseases of the brain such ...
Aug 28, 2013
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Dysfunction of the ubiquitin-proteasome system (UPS) has been detected in many neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and certain types of cancer. Such dysfunction is also believed to be ...
Jul 1, 2013
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Stroke, heart attacks and numerous other common disorders result in a massive destruction of cells and tissues called necrosis. It's a violent event: As each cell dies, its membrane ruptures, releasing substances that trigger ...
Mar 18, 2013
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ICREA professor Raúl Méndez publishes a study in Nature describing how the CPBE1 protein "takes the brakes off" the production of proteins associated with the cell switch from being healthy to tumorous. The study highlights ...
Feb 24, 2013
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