By sifting through the 20,000 protein-encoding genes in the human genome, Yale researchers discovered new complexities behind drug resistance and identified patterns of mutations that could predict which therapies will benefit ...
Dec 11, 2015
0
2
Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment resistance. Scientists at St. Jude Children's Research ...
May 9, 2022
0
26
Oncolytic virology uses live viruses to sense the genetic difference between a tumor and normal cell. Once the virus finds a tumor cell, it replicates inside that cell, kills it and then spreads to adjacent tumor cells to ...
Oct 18, 2011
0
0
Worldwide, more pathogens are becoming resistant to today's antibiotics. As antibiotics lose their efficacy, infections that were once easy to treat can give rise to fatal illnesses.
Nov 15, 2022
0
3
There was no weight gain, despite a higher energy intake, and insulin sensitivity was increased. These are the results from experiments on mice that had elevated levels of the protein BMP4 following gene therapy in a study ...
Aug 24, 2017
0
0
Daily activities, such as fast walking and jogging, can curb the development of risk factors for heart disease and stroke by as much as 50 percent, whereas an hour's daily walk makes little difference, indicates research ...
Oct 9, 2012
0
0
Growing resistance to antibiotics and other antimicrobial treatments is a serious global healthcare challenge. A new study in Antibiotics demonstrates a method for tracking the spread of genes for antimicrobial resistance ...
Mar 28, 2023
0
9
New research suggests that the rapid rise of antibiotic resistance correlates with oral ingestion of antibiotics, raising the possibility that other routes of administration could reduce the spread of resistance. The manuscript ...
Jun 26, 2013
0
0
Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive. To identify previously unknown genes ...
Apr 4, 2023
0
4
Agency for Science, Technology and Research (A*STAR)'s Institute of Medical Biology (IMB) and Singapore Immunology Network (SIgN) have identified a new paradigm for the identification and evaluation of genes for cell survival. ...
Dec 4, 2015
0
1
