Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists.
Sep 2, 2015
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Scientists at VIB and KU Leuven have shown that blocking the PHD1 oxygen sensor hinders the activation of p53, a transcription factor that aids colorectal cancer (CRC) cells in repairing themselves and thus resisting chemotherapy. ...
Aug 19, 2015
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A new computational study published in the International Journal of Bioinformatics Research and Applications has shown how mutations that give rise to drug resistance occur in a form of cancer known as acute myeloid leukemia ...
Aug 4, 2015
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A molecule that helps control gene expression may play a role in controlling chemotherapy resistance among patients with the most common form of ovarian cancer.
May 20, 2015
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49
Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.
Apr 20, 2015
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15
Francis Crick Institute (link is external)scientists, funded by Cancer Research UK, have discovered the timing of key genetic mistakes that fuel tumour growth, according to research published in the journal Science Translational ...
Apr 16, 2015
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Capitalizing on a rare opportunity to thoroughly analyze a tumor from a lung cancer patient who had developed resistance to targeted drug treatment, UC San Francisco scientists identified a biological escape hatch that explains ...
Apr 2, 2015
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For all their lethality, cancer cells don't look much different from healthy cells, a simple fact that causes endless pain and suffering. Finding cancer cells that have spread and threaten to grow into metastatic tumors is ...
Mar 31, 2015
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Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.
Mar 2, 2015
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Powerful drugs known as BRAF-inhibitors have been crucial for melanoma patients, saving lives through their ability to turn off the BRAF protein's power to spur cancer cell growth.
Feb 24, 2015
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