Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies. ...
Jul 6, 2015
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89
Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due ...
Jul 31, 2017
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131
In an unfinished part of his basement, 95-year-old Richard Soller zips around a makeshift track encircling boxes full of medals he's won for track and field and long-distance running.
Aug 31, 2022
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10
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.
Feb 12, 2021
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113
Jeff Bezos is on a mission to conquer aging. He has just recruited Hal Barron from GlaxoSmithKline to help lead Altos Labs, the ambitious new anti-aging company with billions of investment. So what does science really say ...
Jan 24, 2022
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9
In a small safety and feasibility clinical trial, Mayo Clinic researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed "senolytics". The result was verified not ...
Sep 18, 2019
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12
Working with researchers from Stanford University and St. Anna Children's Cancer Research, researchers from Jürgen Pollheimer's laboratory at the Medical University of Vienna's Department of Obstetrics and Gynecology have ...
Oct 15, 2018
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88
Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals. In a review article published online in the Journal of the American Geriatrics ...
Sep 4, 2017
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52
Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers ...
May 15, 2011
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0
Mutating cells can prevent the spread of cancer by flipping themselves into a state of reduced activity called senescence. Cancer genes, however, can retaliate by reviving those cells so they can replicate again.
Apr 21, 2023
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