Medications

Early steroids improve outcomes in patients with septic shock

Some critically ill patients with septic shock need medications called vasopressors to correct dangerously low blood pressure. When high doses of vasopressors are needed or blood pressure isn't responding well, the steroid ...

Diseases, Conditions, Syndromes

Does the COVID-19 cytokine storm exist?

Inflammatory proteins, also known as cytokines, play a crucial role in the immune response. If this immune response is too strong, a phenomenon known as "cytokine storm," it can cause harm to the patient. It has been thought ...

Immunology

The yin and yang of inflammation controlled by a single molecule

Researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified a protein called histone deacetylase 3 (HDAC3) as the orchestrator of the immune system's inflammation response to infection. ...

Immunology

St18 is a negative regulator of VEGF

Pro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopolysaccharide (LPS) are known to activate NF-kB. NF-kB is a master regulator of inflammation and induces pro-inflammatory cytokines. Although ...

Immunology

Antihypotensive agent disrupts the immune system in sepsis

Patients who go into septic shock are treated with the antihypotensive agent norepinephrine. Researchers from Radboud University Medical Center published results in today's American Journal of Respiratory and Critical Care ...

Diseases, Conditions, Syndromes

WHO warns against novel coronavirus 'blanket measures'

The World Health Organization (WHO) on Monday warned against "blanket measures" over the novel coronavirus outbreak, pointing out the epidemic outside of China was only affecting a "tiny" proportion of the population.

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