Medical research

New technique overcomes genetic cause of infertility

Scientists have created healthy offspring from genetically infertile male mice, offering a potential new approach to tackling a common genetic cause of human infertility.

Genetics

For keeping X chromosomes active, chromosome 19 marks the spot

After nearly 40 years of searching, Johns Hopkins researchers report they have identified a part of the human genome that appears to block an RNA responsible for keeping only a single X chromosome active when new female embryos ...

Medical research

New insights into infertility-causing sex chromosome disorders

Research carried out by Francis Crick Institute scientists provides new insights into sex chromosome disorders which typically cause infertility, such as Turner syndrome and Klinefelter syndrome. Through their research, the ...

Medical research

Sex hormones skew outcomes in clinical trials—here's how

Clinical research often excludes females from their trials under the assumption that "one size fits all," that a painkiller or antidepressant will be equally effective in subjects of either sex, but a growing number of scientists ...

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Sex-determination system

A sex-determination system is a biological system that determines the development of sexual characteristics in an organism. Most sexual organisms have two sexes. In many cases, sex determination is genetic: males and females have different alleles or even different genes that specify their sexual morphology. In animals, this is often accompanied by chromosomal differences. In other cases, sex is determined by environmental variables (such as temperature) or social variables (the size of an organism relative to other members of its population). The details of some sex-determination systems are not yet fully understood.

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