An international team of scientists led by researchers at St. Jude Children's Research Hospital has found a way to use CRISPR gene editing to help fix sickle cell disease and beta-thalassemia in blood cells isolated from ...
Aug 15, 2016
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Health experts have long believed that sickle cell gene variants, which occur in about 1 in 13 African-Americans, increase the risk of premature death, even when people carry only a single copy of the variant. But health ...
Aug 3, 2016
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Researchers at Harvard Medical School and Dana-Farber Cancer Institute report that humans have a surprisingly high number of genes in which one of two copies has been randomly silenced. They suggest that the phenomenon is ...
Feb 4, 2016
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Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that changes to a small stretch of DNA may circumvent the genetic defect behind sickle cell disease (SCD). The discovery, published ...
Sep 16, 2015
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UNSW Australia researchers have shown that changing just a single letter of the DNA of human red blood cells in the laboratory increases their production of oxygen-carrying haemoglobin - a world-first advance that could lead ...
May 14, 2015
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The ability to switch out one gene for another in a line of living stem cells has only crossed from science fiction to reality within this decade. As with any new technology, it brings with it both promise—the hope of fixing ...
Jul 9, 2014
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Many rare disorders are caused by gene mutation, like sickle cell anemia. Yet until now the underlying genetic cause of more common conditions – for example, rheumatoid arthritis – has evaded scientists for years.
Dec 20, 2013
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Hematology researchers at The Children's Hospital of Philadelphia have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period. Because this fetal hemoglobin ...
Dec 8, 2013
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Researchers have presented the latest findings from a clinical trial aimed at discovering a cure for sickle cell disease, a painful genetic blood disorder with limited treatment options.
Jun 15, 2024
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Harnessing the body's own cells to fight disease, long a medical dream, is finally a reality.
May 13, 2024
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