Medical research

Understanding tears and regulation of lacrimal gland secretions

The lacrimal gland of the eye secretes a major component of tears, yet surprisingly little is still understood about the signaling pathways that activate lacrimal gland secretions. The most current knowledge of how purinergic ...

Diseases, Conditions, Syndromes

COPD – what causes the lungs to lose their ability to heal?

In chronic obstructive pulmonary disease (COPD), the patients' lungs lose their ability to repair damages on their own. Scientists at the Helmholtz Zentrum München, partner in the German Center for Lung Research (DZL) now ...

Genetics

Scientists find cause of facial widening defects

Widening across the forehead and nose occurs when loss of cilia at the surface of the cells disrupts internal signaling and causes two GLI proteins to stop repressing midfacial growth. Ching-Fang Chang and Samantha Brugmann ...

Genetics

Controlling cell-fate decisions

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial ...

Oncology & Cancer

Analysis of metastatic prostate cancers suggests treatment options

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate ...

Cardiology

Oregon scientists link signaling network to heart valve defects

May 5, 2016—A cell-to-cell signaling network that serves as a developmental timer could provide a framework for better understanding the mechanisms underlying human heart valve disease, say University of Oregon scientists.

Medical research

Stem cell study finds mechanism that controls skin and hair color

A pair of molecular signals controls skin and hair color in mice and humans—and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

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