New research out of the University of Cincinnati examines the association between genetics and the presence of opioid use disorder (OUD). The study identified six single nucleotide polymorphisms (SNPs) or genetic variants ...
Apr 27, 2023
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Endometriosis has a causal link to ischemic stroke, according to a research letter published in the February issue of Stroke, a theme issue focused on the topic of cerebrovascular diseases and women, in conjunction with the ...
Jan 24, 2023
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Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17 in the open access journal ...
Jan 17, 2023
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Bipolar disorder (BD) is causally associated with inflammatory bowel disease (IBD), according to a study published online Sept. 20 in Frontiers in Genetics.
Oct 22, 2022
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Researchers at Vanderbilt University Medical Center have found that the change in a single letter of the genetic code promotes, in a mouse model, the development of inflammation, high blood pressure and resulting kidney damage.
Oct 21, 2022
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Esophageal adenocarcinoma (EAC) is a type of cancer affecting the mucus-secreting glands of the lower esophagus—the tube connecting the throat to the stomach. It is the most common form of esophageal cancer and often preceded ...
Sep 22, 2022
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Cluster headaches, anxiety and depression can be debilitating for people living with these conditions. Psychedelic drugs have shown benefits as treatments for these conditions in clinical studies, but not for everyone. Now, ...
Jul 27, 2022
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To date most research on obesity has focused on studying those with a high body mass index (BMI), but a research group in China is taking a different approach. In a study published July 14 in the journal Cell Metabolism, ...
Jul 14, 2022
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Researchers at the University of Arizona Health Sciences are hoping to catch stomach cancer before it develops in at-risk patients. In a paper published in Gastroenterology, researchers identified a genetic variation that ...
Jun 6, 2022
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Your education, your job, your income, the neighborhood you live in: Together these factors are considered to represent socioeconomic status (SES) and contribute to a variety of health and social outcomes, from physical and ...
May 18, 2022
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A single-nucleotide polymorphism (SNP, pronounced snip) is a DNA sequence variation occurring when a single nucleotide — A, T, C, or G — in the genome (or other shared sequence) differs between members of a species (or between paired chromosomes in an individual). For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. In this case we say that there are two alleles : C and T. Almost all common SNPs have only two alleles.
Within a population, SNPs can be assigned a minor allele frequency — the lowest allele frequency at a locus that is observed in a particular population. This is simply the lesser of the two allele frequencies for single-nucleotide polymorphisms[1]. There are variations between human populations, so a SNP allele that is common in one geographical or ethnic group may be much rarer in another.
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