Pediatric encephalopathies of genetic origin cause severe motor and intellectual disabilities from birth. One of these diseases, first identified in 2013, is caused by mutations in the GNAO1 gene. In order to understand the ...
Oct 10, 2022
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Every time you walk out of a building, you immediately see where you're at and then step toward a destination. Whether you turn left, right or go straight ahead, you don't even think about it. Simple, right?
Sep 13, 2017
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A team of researchers affiliated with multiple institutions in the U.S. has found that reciprocal repulsions of cell-surface molecules prevent tangling in parallel hippocampal networks. In their paper published in the journal ...
In preclinical trials, Stanford scientists and their collaborators harnessed the gene-editing system CRISPR-Cas9 to replace the mutated gene underpinning the devastating immune disease.
Apr 11, 2019
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Sometimes cancer stays put, but often it metastasizes, spreading to new locations in the body. It has long been suspected that genetic mutations arising inside tumor cells drive this potentially devastating turn of events.
May 25, 2020
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Researchers at the RIKEN Center for Genomic Medicine (CGM), together with colleagues at Kyoto University, Tsukuba University, Harvard University, and other medical institutions have identified three new loci associated with ...
Jul 31, 2011
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Enlarged cerebral ventricles are found in 80% of individuals with schizophrenia, yet the mechanisms that lead to ventricular enlargement are mostly unknown. Scientists at St. Jude Children's Research Hospital have found that ...
Feb 14, 2020
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To better appreciate how a complex organ such as the brain functions, scientists strive to accurately understand both its detailed cellular architecture and the intercellular communications taking place within it.
Dec 22, 2021
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Brain organoids—also called mini-brains—are 3-D cellular models that represent aspects of the human brain in the laboratory. Brain organoids help researchers track human development, unravel the molecular events that ...
Aug 29, 2019
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CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize ...
Nov 14, 2023
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