(Medical Xpress)—Until recently, medical researchers had little hope of experimentally manipulating naïve T cells to study their crucial roles in immune function, because they were largely impenetrable, says polymer scientist ...
Oct 11, 2012
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Small interfering RNAs (siRNAs) are a potent new drug class that can silence a disease-causing gene, but delivering them to a target cell can be challenging. An innovative delivery approach that dramatically increases the ...
Dec 21, 2012
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New research suggests that lowering excessive levels of a protein in immune system cells could be a strategy to clear an infection that is deadly to patients with cystic fibrosis (CF).
Jan 23, 2013
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tRNA fragments—small sections of transfer RNA molecules—have recently been discovered to play active roles in the biology of diverse organisms. Now, these tRNA fragments (tRFs) have been found to have important functions ...
Jan 24, 2018
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A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different ...
May 29, 2024
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Jillian Shapiro, a third-year graduate student at the Icahn School of Medicine at Mount Sinai, has been named to the second annual Forbes "30 Under 30" list in "Science and Health." The honorees "reflect the way that the ...
Dec 20, 2012
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A clinical trial of a potential Ebola therapy, led by Oxford University, is underway in Sierra Leone.
Mar 12, 2015
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Researchers have reported the ability to modify the structure of small interfering RNAs (siRNAs) to improve their stability and therapeutic potential without negatively affecting their potency and ability to silence targeted ...
Jan 9, 2018
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To treat the debilitating anemia associated with reduced erythropoietin (EPO) production by the kidneys in chronic renal disease, patients are often given recombinant human EPO to increase hemoglobin levels. But that treatment ...
Oct 16, 2014
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For the first time, large-scale information on the biochemical makeup of small interfering RNA (siRNA) molecules is available publicly. These molecules are used in research to help scientists better understand how genes function ...
Dec 11, 2013
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