Researchers have found an unexpected synergy between a T-cell stimulatory protein—the ICOS ligand—and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice. The study will aid the ...
Mar 25, 2021
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Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, ...
Jan 4, 2021
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89
Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers ...
Dec 7, 2020
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25
An injectable drug used to reduce stubbornly high cholesterol levels appears in animal studies to also enhance the immune response of anti-cancer therapies known as immune checkpoint inhibitors, a study led by Duke Health ...
Nov 12, 2020
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143
People with cancer who exercise generally have a better prognosis than inactive patients. Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth in ...
Oct 26, 2020
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341
Xu Yu, MD, Ragon group leader, recently published a study entitled "Distinct viral reservoirs in individuals with spontaneous control of HIV-1," in Nature. Yu's lab, in collaboration with Ragon group leaders Mathias Lichterfeld, ...
Aug 26, 2020
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In the fight against cancer, the immune system is the first line of defense. The lymphatic system specifically is essential to protecting the body against foreign invaders. Activation of immune cells in the lymph nodes leads ...
Aug 18, 2020
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A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease ...
Jan 30, 2020
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68
Like separate entrance and exit doors on a building, a cell's outer surface has its own doors—channels, pumps, and transporters that selectively control what molecules may enter or exit. In the immune system, T cells—essential ...
Oct 8, 2019
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57
Autophagy contributes to the homeostasis of a cell and recently another function of autophagy has been reported. A KAIST research team found that the autophagy of dendritic cells supports T-cell anticancer activity.
May 13, 2019
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