Scientists at St. Jude Children's Research Hospital are improving chimeric antigen receptor (CAR) T-cell therapy. Their new simplified approach selected for an advantageous T-cell type and showed promise in the lab against ...
Aug 5, 2022
0
39
Scientific advancements have often been held back by the need for high volumes of data, which can be costly, time-consuming, and sometimes difficult to collect. But there may be a solution to this problem when investigating ...
Jul 20, 2022
0
4
Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T-cell therapy for treatment of solid tumors. The results were published today in ...
Jun 22, 2022
0
104
A screening tool developed at the University of Strathclyde, U.K., could increase the number of tests on a solid tumor sample by up to 50 times.
Jun 21, 2022
0
47
T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...
Jun 13, 2022
0
21
Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma receptor (IFNgR) signaling pathway is critical for susceptibility of glioblastoma tumors to killing by CAR T-cell immunotherapy. ...
Jun 10, 2022
0
52
Before a patient can undergo T cell therapy designed to target cancerous tumors, the patient's entire immune system must be destroyed with chemotherapy or radiation. The toxic side effects are well known, including nausea, ...
Jun 8, 2022
0
89
Chimeric antigen receptor T-cell therapy, or CAR T, has made a big impact on the treatment of certain blood cancers, allowing patients with relapsed/refractory disease to live longer, healthier lives. But in clinical study, ...
May 5, 2022
0
51
Immunotherapy has changed the way oncology patients are treated. Immunotherapy approaches, including the use of immunomodulatory agents to enhance anti-cancer responses and the recent development of adoptive cell therapies ...
Apr 21, 2022
0
5
Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can become exhausted, or unable to function properly. One immunotherapy that revitalizes ...
Apr 18, 2022
0
74
