A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University. The research also reveals a new therapy ...
Aug 2, 2024
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Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: Many patients, including those whose cancer goes into full remission, eventually ...
Aug 2, 2024
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One of the most innovative treatments for pediatric cancer today is a novel form of targeted immunotherapy that was recently developed and is now increasingly being applied to pediatric cancer treatment: chimeric antigen ...
Aug 5, 2024
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Scientists at La Jolla Institute for Immunology (LJI) have published the first-ever, in-depth analysis of immune cell memory in the upper airways of adult volunteers. Among these immune cells, the researchers spotted "tissue ...
Jul 31, 2024
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Chimeric antigen receptor (CAR) T–cell immunotherapy re-engineers a patient's immune cells to target cancer cells. While successful in some types of leukemia, the approach has yet to realize its potential against pediatric ...
Aug 5, 2024
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CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the U.S. and a year later in Europe for treating acute lymphoblastic ...
Aug 2, 2024
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A research group led by Kyoto University has produced the world's first pluripotent stem cell-derived killer T-cell drug to treat COVID-19. The University has filed a patent application ahead of full-scale drug development.
Aug 2, 2024
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Mantle cell lymphoma (MCL) is a rare and sometimes ruthless form of non-Hodgkin lymphoma. Even when treatment appears to be successful, the cancer often returns and is difficult to cure.
Aug 2, 2024
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Axicabtagene ciloleucel, commonly known as axi-cel, is an innovative immunotherapy that uses modified T cells to target and destroy cancer cells. Approved for patients who have not responded to at least two prior lines of ...
Aug 5, 2024
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A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins ...
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T cells belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a special receptor on their cell surface called T cell receptors (TCR). The abbreviation T, in T cell, stands for thymus, since this is the principal organ responsible for the T cell's maturation. Several different subsets of T cells have been discovered, each with a distinct function.
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