The discovery of the molecular pathway that drives the changes seen in the brains of Alzheimer's patients is reported today, revealing new targets for drug discovery that could be exploited to combat the disease. The study ...
Nov 20, 2012
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One of the most distinctive signs of the development of Alzheimer's disease is a change in the behavior of a protein that neuroscientists call tau. In normal brains, tau is present in individual units essential to neuron ...
Feb 2, 2012
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Depression is one of the most common mental disorders in the elderly, but little is known about the underlying biology of its development in older adults.
Nov 8, 2011
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Researchers at the RIKEN Brain Science Institute (BSI) and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer's disease (AD). Their surprising findings reveal that ...
Jul 3, 2011
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On Jan. 31, aducanumab, a pricey drug approved for treatment of early-stage Alzheimer's disease, was withdrawn from the market. And in early March, the Food and Drug Administration delayed its decision regarding whether to ...
Mar 14, 2024
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Early stages of neurodegenerative disorders are characterized by the accumulation of proteins in discrete populations of brain cells and the degeneration of these cells. For most diseases, this selective vulnerability pattern ...
Mar 11, 2024
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The effects of Alzheimer's disease are devastating: not being able to recognize loved ones, losing precious memories, losing the ability to perform simple tasks, suffering through mood swings, and so on. Not only are memory ...
Jan 18, 2024
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With the rise of new drugs that can target the amyloid-beta plaques in the brain that are an early sign of Alzheimer's disease, new ways are needed to determine whether memory loss and thinking problems are due to Alzheimer's ...
Nov 15, 2023
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Diseases that run in families usually have genetic causes. Some are genetic mutations that directly cause the disease if inherited. Others are risk genes that affect the body in a way that increases the chance someone will ...
Sep 15, 2023
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A panel of 48 proteins in the cerebrospinal fluid (CSF 48 panel) complements existing CSF biomarkers for Alzheimer disease (AD), according to a study published in the Sept. 6 issue of Science Translational Medicine.
Sep 8, 2023
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