Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation. Proteolysis-targeting chimeras or PROTACs are a promising type ...
Aug 26, 2020
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Since the late 1990s, immunotherapy has been the frontline treatment against lymphomas where synthetic antibodies are used to stop the proliferation of cancerous white blood cells. However, in the more than 20 years since ...
Aug 13, 2020
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Scientists at the University of California, Riverside, have used machine learning to identify hundreds of new potential drugs that could help treat COVID-19, the disease caused by the novel coronavirus, or SARS-CoV-2.
Aug 12, 2020
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Researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified a protein called histone deacetylase 3 (HDAC3) as the orchestrator of the immune system's inflammation response to infection. ...
Aug 5, 2020
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Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.
Jul 28, 2020
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In immune-related disorders, therapy often involves identifying the molecules responsible for immune dysregulation and targeting them using drugs. This type of immune therapy is also used for cancer treatment, owing to the ...
Jul 21, 2020
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A method known as CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient's own T-cells by adding a piece of an antibody that recognizes unique features ...
Jun 29, 2020
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Amyloids are particular protein assemblies with properties similar to silk, that serve numerous functions. They also form upon protein misfolding resulting in protein inactivation.
Jun 9, 2020
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In the last several years, excitement has surged for a promising class of drugs that work not by inhibiting the action of a molecular target, as most conventional drugs do, but instead by harnessing the cell's recycling system ...
Jun 4, 2020
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Normally, the immune system is able to differentiate between healthy and abnormal cells. Peptides, fragments created by the synthesis and breakdown of proteins inside each cell, are presented on the surface as antigens and ...
Jun 2, 2020
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